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The ethics of disease-modifying drugs targeting Alzheimer disease: response to our commentators
  1. Erik Gustavsson1,2,
  2. Pauline Raaschou3,
  3. Gerd Lärfars4,
  4. Lars Sandman2,
  5. Niklas Juth5
  1. 1 Centre for Applied Ethics, Department of Culture and Society, Linköping University, Linköping, Sweden
  2. 2 The National Centre for Priorities in Health, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden
  3. 3 Clinical Pharmacology Unit, Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
  4. 4 Health and Medical Care Administration, Stockholm, Sweden
  5. 5 Stockholm Centre of Healthcare Ethics, LIME, Karolinska Institute, Stockholm, Sweden
  1. Correspondence to Erik Gustavsson, Department of Culture and Society, Linköping University, Linkoping, Sweden; erik.gustavsson{at}

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In Gustavsson et al,1 we discussed the ethical issues that arise when identifying the relevant population for disease-modifying drugs targeting Alzheimer disease (AD). More specifically, we focused on novel immunotherapies aimed at amyloid β and tau, two relevant biomarkers. The commentaries to our paper2 3 acknowledge our conclusion: screening for AD involve ethical costs that cannot be justified unless a drug with clinically relevant effect (with acceptable safety) becomes available.

Since Aduhelm is the only immunotherapy targeting AD currently approved by the Food and Drug Administration, we use that as a …

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  • Contributors EG drafted the response and collaborated with PR, NJ, GL and LS in its finalisation. All authors authorised the final version before submission.

  • Funding This research was supported by the Stockholm County Council.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.