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Commentary to ‘Novel drug candidates targeting Alzheimer’s disease: ethical challenges with identifying the relevant patient population’
  1. Maria Eriksdotter1,2
  1. 1 Department of Neurobiology, Karolinska Institutet, Stockholm, Sweden
  2. 2 Theme Inflammation and Aging, Karolinska University Hospital, Huddinge, Sweden
  1. Correspondence to Professor Maria Eriksdotter, Department of Neurobiology, Karolinska Institutet, Stockholm 141 83, Sweden; Maria.Eriksdotter{at}ki.se

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The article by Gustavsson et al 1 addresses the important question how to handle new medications with focus on drug candidates that reduce Aβ or tau in the brain, for individuals with Alzheimer’s disease (AD), where the need for a disease-modifying drug is enormous.

There are several ethical issues to deal with. The challenges and ethical implications associated with whom should be eligible for treatment are thoroughly discussed in the article. Should treatment only be available to those with mild symptoms and/or to those with no symptoms but with risk for AD? Where do we draw the line between who will be eligible for treatment and who will not? Who will be responsible for the prioritisation?

There are many ethical problems with both population screening and screening of those with high risk well discussed in the article. Indeed, the first immunotherapy drug Aducanumab was approved by the US Food and Drug Administration (FDA)in …

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Footnotes

  • Funding There is no specific grant for this commentary from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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