Footnotes

• Funding JK and DW, through their involvement with the Murdoch Children’s Research Institute, received support from the Victorian State Government through the Operational Infrastructure Support (OIS) Programme. DW was supported for this work by a grant from the Wellcome trust (WT106587/Z/14/Z). DW would also like to acknowledge the generous support of the Russell and Mab Grimwade Miegunyah Fund; part of this work was undertaken while he was a Miegunyah distinguished visiting research fellow at the University of Melbourne.

• Competing interests None declared.

• Provenance and peer review Not commissioned; internally peer reviewed.

• Patient consent for publication Not required.