Article info
PDFExtended essay
Learning health systems, clinical equipoise and the ethics of response adaptive randomisation
- Correspondence to Dr Alex John London, Center for Ethics and Policy, Carnegie Mellon University, Pittsburgh, PA 15213-3890, USA; ajlondon{at}andrew.cmu.edu
Citation
Learning health systems, clinical equipoise and the ethics of response adaptive randomisation
Publication history
- Received August 30, 2017
- Revised November 6, 2017
- Accepted November 14, 2017
- First published November 24, 2017.
Online issue publication
May 24, 2018
Article Versions
- Previous version (24 May 2018).
- You are viewing the most recent version of this article.
Request permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Copyright information
© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.
Other content recommended for you
- Equipoise, standard of care and consent: responding to the authorisation of new COVID-19 treatments in randomised controlled trials
- Non-static framework for understanding adaptive designs: an ethical justification in paediatric trials
- Assessing research risks systematically: the net risks test
- Equipoise dumbbell
- Contextual equipoise: a novel concept to inform ethical implications for implementation research in low-income and middle-income countries
- Refuting the net risks test: a response to Wendler and Miller’s “Assessing research risks systematically”
- Distinguishing treatment from research: a functional approach
- Reconsidering ‘minimal risk’ to expand the repertoire of trials with waiver of informed consent for research
- Position statement on ethics, equipoise and research on charged particle radiation therapy
- Estimating the social value of mechanical thrombectomy randomized trials on an established stroke network