Article Text
PDF
Abstract
Combination antiretroviral therapy (cART) is highly effective at preventing morbidity and mortality due to infection with human immunodeficiency virus (HIV), but does not eradicate the virus. Consequently, cART must be administered life-long. Recent progress has stimulated research towards a cure of HIV infection. Approaches under investigation include hematopoietic stem cell transplantation, latency reactivating agents, immune based therapies, and cell-based therapies. Each of these approaches carries potential risks that must be weighed against the availability of safe and effective cART. Balancing the risks and benefits of this research poses unique challenges to potential study participants, clinicians and investigators.
- HIV Infection and AIDS
- Clinical trials
- Ethics
This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Statistics from Altmetric.com
Footnotes
Funding National Institute of Allergy and Infectious Diseases (1 R01 AI114617-01A1), (1 R56 AI114617-01) and (UM1 AI068636).
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
Other content recommended for you
- HIV associated pulmonary emphysema: a review of the literature and inquiry into its mechanism
- Cardiovascular manifestations of HIV infection
- Pathogenesis of Anemia During Human Immunodeficiency Virus Infection
- Diminished frequency of hepatitis C virus specific interferon γ secreting CD4+ T cells in human immunodeficiency virus/hepatitis C virus coinfected patients
- Monitoring patients with HIV disease
- Safety of antitumour necrosis factor (anti-TNF) therapy in patients with chronic viral infections: hepatitis C, hepatitis B, and HIV infection
- Increased polymorphonuclear leucocyte rigidity in HIV infected individuals
- Allergy, immunity, and infection
- Major advances in the treatment of HIV-1 infection
- Human immunodeficiency virus associated spondyloarthropathy: pathogenic insights based on imaging findings and response to highly active antiretroviral treatment