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The benefit/risk ratio challenge in clinical research, and the case of HIV cure: an introduction
  1. Nir Eyal
  1. Correspondence to Professor Nir Eyal, Department of Global Health and Population, Harvard TH Chan School of Public Health, 651 Huntington Ave., FXB Building, Boston, MA 02139, USA; neyal{at}


This piece introduces the JME symposium ‘The benefit/risk ratio challenge in clinical research, and the case of HIV cure.’

  • HIV Infection and AIDS
  • Research Ethics
  • Ethics

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

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  • Funding This work was funded by NIAID grants 1 R01 AI114617-01A1 and 1 R56 AI114617-01, both titled ‘HIV cure studies: risk, risk perception, and ethics’.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; internally peer reviewed.

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