Article Text
Statistics from Altmetric.com
A new study published in Journal of Medical Ethics by van der Zande et al 1 further highlights why classifying pregnant women as a ‘vulnerable population’ in the context of research is deeply problematic. Because the designation of ‘vulnerable’ is otherwise applied to populations whose decision-making capacity about research participation is somehow compromised—such as children and adults of limited cognitive ability—many of us have been arguing for some time that using this designation for pregnant women is inappropriate and disrespectful.2–4 There is nothing about the state of pregnancy that renders pregnant women incapable of offering valid research consents or refusals. Moreover, rather than protecting the health interests of pregnant women and their offspring, this designation has had the opposite effect. It has contributed to the widespread exclusion of pregnant women from research activities, which is itself pernicious to the health of pregnant women.5
We know that pregnant women encounter a range of health needs across their pregnancies. In the USA, for example, approximately 9 out of every 10 women use some kind of medication during pregnancy to manage health conditions.6 Yet because pregnant women have largely been …
Footnotes
Contributors CBK drafted the commentary with substantive input and edits from RRF.
Funding The work referenced in this commentary was supported by the Wellcome Trust (grant number: 203160/Z/16/Z) and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (award number: R01 AI108368-01A1). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Wellcome Trust.
Competing interests None declared.
Provenance and peer review Commissioned; internally peer reviewed.
Correction notice This article has been corrected since it was published Online First. Funding information have been added.
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Copyright information:
Linked Articles
- Research ethics
Read the full text or download the PDF:
Other content recommended for you
- Vulnerability of pregnant women in clinical research
- Understanding the relation between Zika virus infection during pregnancy and adverse fetal, infant and child outcomes: a protocol for a systematic review and individual participant data meta-analysis of longitudinal studies of pregnant women and their infants and children
- Assent in paediatric research: theoretical and practical considerations
- ‘ It all dials back to safety ’: A qualitative study of social and economic vulnerabilities among transgender women participating in HIV research in the USA
- Maternal - fetal transmission and adverse perinatal outcomes in pregnant women infected with Zika virus: prospective cohort study in French Guiana
- Cohort profile: the Jundiaí Zika cohort (JZC), a pregnancy and birth cohort in São Paulo state, Brazil
- Use of infectious disease surveillance reports to monitor the Zika virus epidemic in Latin America and the Caribbean from 2015 to 2017: strengths and deficiencies
- Assessing the population at risk of Zika virus in Asia – is the emergency really over
- Outbreak of Zika virus disease in the Americas and the association with microcephaly, congenital malformations and Guillain – Barré syndrome
- Meeting the goal of concurrent adolescent and adult licensure of HIV prevention and treatment strategies