Minimising the use of animals in experiments is universally recognised by scientists, governments and advocates as an ethical cornerstone of research. Yet, despite growing public opposition to animal experimentation, mounting evidence that animal studies often do not translate to humans, and the development of new research technologies, a number of countries have reported increased animal use in recent years. In the USA—one of the world's largest users of animals in experiments—a lack of published data on the species most commonly used in laboratories (eg, mice, rats and fish) has prevented such assessments. The current study aimed to fill this gap by analysing the use of all vertebrate animals by the top institutional recipients of National Institutes of Health research funds over a 15-year period. These data show a statistically significant 72.7% increase in the use of animals at these US facilities during this time period—driven primarily by increases in the use of mice. Our results highlight a need for greater efforts to reduce animal use. We discuss technical, institutional, sociological and psychological explanations for this trend.
- Animal Experimentation
- Research Ethics
- Policy Guidelines/Inst. Review Boards/Review Cttes.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Read the full text or download the PDF:
Other content recommended for you
- Reforming the politics of animal research
- What is the optimum design for my animal experiment?
- Is there a place for animal experiments?
- Animal experiments rose in 2011 despite coalition pledge to reduce them
- Antimicrobial use in food-producing animals: a rapid evidence assessment of stakeholder practices and beliefs
- Comparison of different approaches to antibiotic restriction in food-producing animals: stratified results from a systematic review and meta-analysis
- Ethical issues when modelling brain disorders innon-human primates
- Scotland seeks views on banning wild animals in travelling circuses
- Animals in medical training and research: transforming perceptions in medical schools, India
- Pets in clinical trials