The randomised controlled trial (RCT) constitutes a quantitative, comparative, controlled study of a particular treatment, and provides invaluable evidence regarding its pharmacotherapeutic efficacy. These studies are generally predicated upon the ethical principle of clinical equipoise. However, this may be insufficient to justify withholding treatment from a control group while assessing drug therapy in a potentially fatal disease. Thus, the criteria for randomisation, informed consent methodology and timing, and consideration of treatment options in such a scenario remain the province of medical ethics. This paper addresses the need for an RCT of ribavirin in the treatment of Crimean Congo haemorrhagic fever, and highlights underlying ethical concerns in light of the current medical, virological and ethical literature.
- Crimean Congo haemorrhagic fever
- randomised controlled trial
- informed consent
- publishing ethics
- human rights in medicine
- ethics education
- legal aspects
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Competing interests None.
Provenance and peer review Not commissioned; externally peer reviewed.
Read the full text or download the PDF:
Other content recommended for you
- Diagnostic tests for Crimean-Congo haemorrhagic fever: a widespread tickborne disease
- Crimean-Congo haemorrhagic fever presenting with acute compartment syndrome of the extremities (think beyond normal infections)
- Severe Crimean–Congo haemorrhagic fever presented with massive retroperitoneal haemorrhage that recovered without antiviral treatment
- Interferon-stimulated gene 15: a dual activity during hepatitis C virus infection
- Viral haemorrhagic fever in children
- Potential pathway for Crimean Congo haemorrhagic fever virus to enter the UK
- A renewed, ethical defense of placebo-controlled trials of new treatments for major depression and anxiety disorders
- Respiratory syncytial virus infection in adults
- Randomised placebo-controlled trials of surgery: ethical analysis and guidelines
- Severe acute respiratory syndrome: report of treatment and outcome after a major outbreak