Article Text
Abstract
Preimplantation tissue typing has been proposed as a method for creating a tissue matched child that can serve as a haematopoietic stem cell donor to save its sick sibling in need of a stem cell transplant. Despite recent promising results, many people have expressed their disapproval of this method. This paper addresses the main concerns of these critics: the risk of preimplantation genetic diagnosis (PGD) for the child to be born; the intention to have a donor child; the limits that should be placed on what may be done to the donor child, and whether the intended recipient can be someone other than a sibling. The author will show that these concerns do not constitute a sufficient ground to forbid people to use this technique to save not only a sibling, but also any other loved one’s life. Finally, the author briefly deals with two alternative scenarios: the creation of a human leukocyte antigen (HLA) matched child as an insurance policy, and the banking of HLA matched embryos.
- DBA, diamond blackfan anaemia
- HLA, human leukocyte antigen, HSC, haematopoietic stem cell
- PGD, preimplantation genetic diagnosis
- histocompatibility testing
- preimplantation diagnosis
- haematopoietic stem cells
- tissue donors
- embryo
Statistics from Altmetric.com
Footnotes
-
↵i A person’s human leukocyte antigen type is determined by her antigen pattern, that is, the markers on the surface of body cells and tissues. They are used by the immune system to distinguish one’s own body cells and tissues from foreign ones.
-
↵ii In the Curry case a couple in the US had a daughter, Natalie Curry, with Fanconi’s anaemia. The couple decided to have another child in the hope that it would be a tissue match for Natalie. The woman became pregnant, but the fetus miscarried. After one month she was pregnant again, and a healthy baby, Audrey, was born. Unfortunately, Audrey was an unsuitable donor. Within 12 weeks the woman was pregnant again. Emily was born healthy and was a match. Twenty months after Emily’s birth, cord blood was transplanted into her sister, who was then four years old. Two years later Natalie was cured.4
-
↵iii Thanks to Nick Bostrom for very helpful feedback.
Request Permissions
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Copyright information:
Other content recommended for you
- Britain ’s new preimplantation tissue typing policy: an ethical defence
- Extending preimplantation genetic diagnosis: medical and non-medical uses
- Ethics of using preimplantation genetic diagnosis to select a stem cell donor for an existing person
- An analysis of US fertility centre educational materials suggests that informed consent for preimplantation genetic diagnosis may be inadequate
- Is conceiving a child to benefit another against the interests of the new child
- Preimplantation genetic diagnosis in clinical practice
- Commodification of children again and non-disclosure preimplantation genetic diagnosis for Huntington ’s disease
- Sex selection for social purposes in Israel: quest for the “ perfect child ” of a particular gender or centuries old prejudice against women
- Gender “ tailored ” conceptions: should the option of embryo gender selection be available to infertile couples undergoing assisted reproductive technology
- Prenatal screening and prenatal diagnosis: contemporary practices in light of the past