Article Text

Download PDFPDF
Sham neurosurgery in patients with Parkinson's disease: is it morally acceptable?
  1. Wim Dekkers,
  2. Gerard Boer
  1. University Medical Centre, Nijmegen, the Netherlands and Netherlands Institute for Brain Research, Amsterdam, the Netherlands


    For a few decades, patients with Parkinson's disease (PD) have been treated with intracerebral transplantations of fetal mesencephalic tissue. The results of open trials have been variable. Double blind, placebo-controlled studies have recently been started in order to further investigate the efficacy of this new medical technique. In this paper we challenge the need for sham surgery in neurotransplantation research on PD patients. Considerations regarding the research subjects' informed consent, therapeutic misconception, the integrity of the human body, and the assessment of risks and benefits argue against sham surgery for patients with PD. Moreover, there is an alternative, less harmful mode of research that can provide the same or comparable scientific evidence. A plea is made for intrapatient research based on quantitative measurements of the patient's pre- and post-operative condition combined with similar research on a reference group of patients who have received the standard treatment.

    • Neural grafting
    • Parkinson's disease
    • research ethics
    • sham surgery

    Statistics from

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


    • Wim Dekkers, MD, PhD, is Senior Lecturer in Medical Philosophy, Department of Ethics, Philosophy and History of Medicine, University Medical Centre, Nijmegen and Senior Researcher, Centre for Ethics, University of Nijmegen, the Netherlands. Gerard Boer, PhD, is Senior Researcher, Netherlands Institute for Brain Research, Amsterdam, the Netherlands.

    Other content recommended for you