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Clinical trials: two neglected ethical issues.
  1. A Herxheimer
  1. UK Cochrane Centre, University of Oxford.


    Ethical reasons are presented for requiring 1) that a proposal for a clinical trial should be accompanied by a thorough review of all previous trials that have examined the same and closely related questions, and 2) that a trial should be approved by a research ethics committee only if the investigator undertakes to register it in an appropriate register of clinical trials as soon as one exists.

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