Objectives Effective and efficient communication is crucial in healthcare. Written
communication remains the most prevalent form of communication between specialised and …

If the great 16th century French surgeon, Ambrose Paré, who stopped the practice of pouring
boiling oil into gunshot wounds, were to return today, what would impress him most about …

The biogenesis of exosomes, small secreted vesicles involved in signalling processes,
remains incompletely understood. Here, we report evidence that the syndecan heparan …

The in vivo requirements for human natural killer (NK) cell development and differentiation
into cytotoxic effectors expressing inhibitory receptors for self–major histocompatability …

Abstract Soluble interleukin (IL)-15 exists under two forms: as monomer (sIL-15) or as
heterodimeric complex in association with sIL-15Rα (sIL-15/IL-15Rα). Both forms have been …

Background. The efficacy of preventing perinatal transmission (PT) of human
immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment …

Background Target-controlled infusion (TCI) systems can control the concentration in the
plasma or at the site of drug effect. A TCI system that targets the effect site should be able to …

Background This report describes a new closed-loop control system for propofol that uses
the Bispectral Index (BIS) as the controlled variable in a patient-individualized, adaptive …

Background Autoregressive modeling with exogenous input of middle-latency auditory
evoked potential (A-Line autoregressive index [AAI]) has been proposed for monitoring …

Toll-like receptors (TLRs) on host cells are chronically engaged by microbial ligands during
homeostatic conditions. These signals do not cause inflammatory immune responses in …