Abstract
Cases of drug-induced aplastic anaemia, haemolytic anaemia, thrombocytopenia, and agranulocytosis reported to the Swedish Adverse Drug Reaction Committee during the five-year period 1966-70 have been analysed and compared with cases of the same cytopenias from "all" causes. Oral diuretics were a dominant cause of drug-induced thrombocytopenia, methyldopa of haemolytic anaemia, and oxyphenbutazone of aplastic anaemia. Computer systems should help such studies, particularly in showing a changing pattern of complications and causes.
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Age Factors
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Aged
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Agranulocytosis / chemically induced*
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Agranulocytosis / epidemiology
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Anemia, Aplastic / chemically induced*
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Anemia, Aplastic / epidemiology
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Anemia, Hemolytic / chemically induced*
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Anemia, Hemolytic / epidemiology
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Child
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Child, Preschool
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Computers
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Diuretics / administration & dosage
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Diuretics / adverse effects
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Female
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Humans
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Infant
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Infant, Newborn
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Male
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Methyldopa / adverse effects
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Middle Aged
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Oxyphenbutazone / adverse effects
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Sex Factors
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Sweden
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Thrombocytopenia / chemically induced*
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Thrombocytopenia / epidemiology
Substances
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Diuretics
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Methyldopa
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Oxyphenbutazone