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Are somatic stem cells pluripotent or lineage-restricted?

Nature Medicine volume 8, pages 213–214 (2002)Cite this article

The finding that fetal mouse neural stem cells do not differentiate into hematopoietic cells contradicts findings from earlier reports and adds to the controversy regarding the rigor of the experimental methods used to demonstrate the differentiation repertoire of stem cells. (pages 268–273)

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Figure 1: Schematic of the Morshead et al. experimental paradigm.
Figure 2: Possible mechanisms for hematopoietic competence of neural stem cells (NSCs).

References

  1. Bartlett, P.F. Pluripotential hematopoietic stem cells in adult mouse brain. PNAS 79, 2722–2725 (1982).

    Article  CAS  Google Scholar 

  2. Bjornson, C.R.R. et al. Turning brain in to blood: A hematopoeitic fate adopted by adult neural stem cells in vivo. Science 283, 534–537 (1999).

    Article  CAS  Google Scholar 

  3. Shih, C.-C. et al. Identification of a candidate human neurohematopoietic stem-cell population. Blood 98, 2412–2422 (2001).

    Article  CAS  Google Scholar 

  4. Morshead, C.M. et al. Hematopoietic competence is a rare property of neural stem cells that may depend on genetic and epigenetic alterations. Nature Med. 8, 268–273 (2002).

    Article  CAS  Google Scholar 

  5. Wulf, G.G., Jackson, K.A. & Goodell, M.A. Somatic stem cell plasticity: Current evidence and emerging concepts. Exp. Hematol. 29, 1361–1370 (2001).

    Article  CAS  Google Scholar 

  6. Anderson, D.J. et al. Can stem cells cross lineage boundaries? Nature Med. 7, 393–395 (2001).

    Article  CAS  Google Scholar 

  7. Clarke, D.L. et al. Generalized potential of adult neural stem cells. Science 288, 1660–1663 (2000).

    Article  CAS  Google Scholar 

  8. Tropepe, V. et al. Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon. Dev. Biol. 208, 166–188 (1999).

    Article  CAS  Google Scholar 

  9. Keyoung, H.M. et al. High yield selection and extraction of two promoter-defined phenotypes of neural stem cells from the fetal human brain. Nature Biotech. 19, 843–850 (2001).

    Article  CAS  Google Scholar 

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  1. Laboratory of Genetics, Salk Institute, La Jolla, California, USA

    Kevin A. D'Amour & Fred H. Gage

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  1. Kevin A. D'Amour
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  2. Fred H. Gage
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D'Amour, K., Gage, F. Are somatic stem cells pluripotent or lineage-restricted?. Nat Med 8, 213–214 (2002). https://doi.org/10.1038/nm0302-213

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