Elsevier

Biological Psychiatry

Volume 72, Issue 12, 15 December 2012, Pages 980-981
Biological Psychiatry

Commentary
What Is the Nature of Serotonergic Abnormalities in Human Aggression?

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    It has been reported that lower serotonergic responsivity in hyperkinetic children may predict the development of conduct and antisocial personality disorders.14 It has also been suggested that impulsive aggressive symptoms are associated with reduced serotonin uptake, increased synaptic levels of serotonin, and reduced postsynaptic receptor responsiveness.15 Previous studies using positron emission tomography (PET) found that abnormal levels of serotonin in the brain were associated with aggressive/impulsive behaviors.16

  • The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake

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    Indeed, these animals display a ∼40% reduction in spontaneous firing of 5-HT neurons in the dorsal raphë (Evrard et al., 2002). In line with this concept, reduced presynaptic corticolimbic 5-HT activity has been posited as a vulnerability factor for aggressive behaviors (Siever, 2008; Coccaro et al., 2011; Rylands et al., 2012; Coccaro, 2012). It is possible that high 5-HT levels during early developmental stages in MAO-A-deficient animals may produce a compensatory decrease in 5-HT neuronal activity, as well as a desensitization of postsynaptic receptors.

  • Serotonin<inf>2A/C</inf> receptors mediate the aggressive phenotype of TLX gene knockout mice

    2013, Behavioural Brain Research
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    In spite of the small number of −/− TLX mice used in the current study, our findings add to these previous experiments by suggesting that 5-HT2 receptors mediate the highly aggressive phenotype. Although several serotonin receptor subtypes have been found to be associated with aggression [22–25], the current experiments extend the research base on the 5-HT2 receptor family. Our initial experiment used clozapine, which targets D4 receptors as well as 5-HT2A/C receptors and produced reductions in aggression across genotypes and potential increases in locomotion in −/− TLX.

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