Skip to main content
Log in

Predictive genetic testing in children: where are we now? An overview and a UK perspective

  • Published:
Familial Cancer Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Notes

  1. Personal experience of authors.

References

  1. Clarke A (1994) The genetic testing of children. Working Party of the Clinical Genetics Society (UK). J Med Genet 31:785–797

    Article  CAS  PubMed  Google Scholar 

  2. Borry P, Stultiens L, Nys H, Cassiman JJ, Dierickx K (2006) Presymptomatic and predictive genetic testing in minors: a systematic review of guidelines and position papers. Clin Genet 70:374–381

    Article  CAS  PubMed  Google Scholar 

  3. Borry P, Fryns JP, Schotsmans P, Dierickx K (2006) Carrier testing in minors: a systematic review of guidelines and position papers. Eur J Hum Genet 14:133–138

    Article  PubMed  Google Scholar 

  4. ESHG guidelines on genetic testing of minors. ESHG guidelines genetic testing of minors; http://www.eshg.org/documents/TestingInMinorsRecommendations.pdf. ESHG

  5. Genethics Club http://www.genethicsclub.org

  6. UK Cancer Genetics Group annual conference May 2007 (2009). http://www.ukcgg.org. Genetic testing of children for cancer predisposition syndromes. 1-5-2009

  7. Clarke A (1998) Genetic testing of Children. Bios Scientific Publishers Ltd, Oxford

    Google Scholar 

  8. Conkie-Rosell A, Spiridigliozzi GA (2004) Family matters: a conceptual framework for genetic testing in children. J Genet Couns 13:9–29

    Article  Google Scholar 

  9. Pelias MK (2006) Genetic testing of children for adult-onset diseases: is testing in the child’s best interests? Mt Sinai J Med 73:605–608

    PubMed  Google Scholar 

  10. Rhodes R (2006) Why test children for adult-onset genetic diseases? Mt Sinai J Med 73:609–616

    PubMed  Google Scholar 

  11. Robertson S, Savulescu J (2001) Is there a case in favour of predictive genetic testing in young children? Bioethics 15:26–49

    Article  CAS  PubMed  Google Scholar 

  12. Craufurd D, Dodge A, Kerzin-Storrar L, Harris R (1989) Uptake of presymptomatic predictive testing for Huntington’s disease. Lancet 2:603–605

    Article  CAS  PubMed  Google Scholar 

  13. Craufurd D, Tyler A (1992) Predictive testing for Huntington’s disease: protocol of the UK Huntington’s Prediction Consortium. J Med Genet 29:915–918

    Article  CAS  PubMed  Google Scholar 

  14. Parsons EP, Clarke AJ, Bradley DM (2003) Implications of carrier identification in newborn screening for cystic fibrosis. Arch Dis Child Fetal Neonatal Ed 88:F467–F471

    Article  CAS  PubMed  Google Scholar 

  15. Borry P, Fryns JP, Schotsmans P, Dierickx K (2005) Attitudes towards carrier testing in minors: a systematic review. Genet Couns 16:341–352

    CAS  PubMed  Google Scholar 

  16. Jarvinen O, Aalto AM, Lehesjoki AE, Lindlof M, Soderling I, Uutela A et al (1999) Carrier testing of children for two X linked diseases in a family based setting: a retrospective long term psychosocial evaluation. J Med Genet 36:615–620

    CAS  PubMed  Google Scholar 

  17. Duncan RE (2004) Predictive genetic testing in young people: when is it appropriate? J.Paediatr Child Health 40:593–595

    Article  CAS  PubMed  Google Scholar 

  18. Duncan RE, Delatycki MB (2006) Predictive genetic testing in young people for adult-onset conditions: where is the empirical evidence? Clin Genet 69:8–16

    Article  CAS  PubMed  Google Scholar 

  19. Michie S, McDonald V, Bobrow M, McKeown C, Marteau T (1996) Parents’ responses to predictive genetic testing in their children: report of a single case study. J Med Genet 33:313–318

    Article  CAS  PubMed  Google Scholar 

  20. Michie S, Bobrow M, Marteau TM (2001) Predictive genetic testing in children and adults: a study of emotional impact. J Med Genet 38:519–526

    Article  CAS  PubMed  Google Scholar 

  21. Duncan RE, Savulescu J, Gillam L, Williamson R, Delatycki MB (2005) An international survey of predictive genetic testing in children for adult onset conditions. Genet Med 7:390–396

    Article  PubMed  Google Scholar 

  22. Parker M (2009) Genetic testing in children and young people. Familial Cancer. doi:10.1007/s10689-009-9272-6

  23. Dalby S (1995) GIG response to the UK Clinical Genetics Society report The genetic testing of children. J Med Genet 32:490–491

    Article  CAS  PubMed  Google Scholar 

  24. Fenwick A (2009) Are guidelines for genetic testing of children necessary? Familial Cancer. doi:10.1007/s10689-009-9278-0

  25. BBCR4 Inside the ethics committee. http:, and www.bbc.co.uk/radio4/science/ethicscommittee_20080820.shtml. Genetic Testing and Adoption. 20-8-2008

  26. Aktan-Collan K, Mecklin JP, Jarvinen H, Nystrom-Lahti M, Peltomaki P, Soderling I et al (2000) Predictive genetic testing for hereditary non-polyposis colorectal cancer: uptake and long-term satisfaction. Int J Cancer 89:44–50

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Anneke Lucassen.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lucassen, A., Montgomery, J. Predictive genetic testing in children: where are we now? An overview and a UK perspective. Familial Cancer 9, 3–7 (2010). https://doi.org/10.1007/s10689-009-9299-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10689-009-9299-8

Keywords

Navigation