Table 1

Studies that met inclusion criteria

	Author (year)	Population	Intervention	Comparison	Outcome	Result
Trial	Eggermont et al (2015)10	Patients with stage III cutaneous melanoma	Intravenous infusions of ipilimumab	Placebo	Recurrence-free survival	Statistically significant improved recurrence-free survival
Systematic review	Mocellin et al (2010)11	Patients with high-risk cutaneous melanoma	Interferon-alpha (IFN-α)	Observation or any other regimen other than IFN-α	Disease-free survival	Statistically significant improved recurrence-free survival
Trial	Symonds et al (2015)12	Women with metastatic or recurrent cervical cancer	Addition of cediranib to carboplatin and paclitaxel chemotherapy	Placebo	Progression-free survival	Cediranib has significant efficacy when added to carboplatin and paclitaxel
Systematic review	Hirte et al (2007)18	Women with recurrent, metastatic or persistent cervical cancer	Front-line chemotherapeutic options (single agent cisplatin)	Another chemotherapy regmine or no treatment	Progression-free survival	Cisplatin in combination with topotecan showed the greatest median overall survival benefit.
Trial	Berwaerts et al (2015)13	Patients with schizophernia	Once-a-month dose of paliperiodone palmitate followed by a dose of 3-month formulation	Placebo	Time from randomisation to first relapse event	Significantly delayed time to relapse
Systematic review	Kishimoto et al (2013)19	Patients with schizophrenia	Second generation antipsychotics (SGAs)	First generation antipsychotics (FGAs)	Study-defined relapse	SGAs were associated with less study-defined relapse, overall treatment failure and hospitalisation than FGAs, having a modest but clinically relevant effect size.
Trial	Valente et al (2015)14	Patients with oedema and ecchymosis following rhinoplasty	Dexamethasone intravenously before surgery	Normal saline solution	Degree of oedema and ecchymosis	Preoperative use of dexamethasone-reduced oedema and ecchymosis
Systematic review	Hatef et al (2011)15	Patients with oedema and ecchymosis following rhinoplasty	Preoperative steroid use	Postoperative steroid use	Degree of oedema and ecchymosis	Perioperative steroid use decreases postoperative oedema and ecchymosis associated with rhinoplasty.