Information to participants and parents
| In children with growth problems it may be necessary to investigate the concentration of growth regulating hormones in the blood to see if they are normal. One of the hormones is insulin-like growth factor-1 (IGF-1). It is now possible to measure the hormone by a new analysis, which we call free IGF-1. |
| Children with poor growth often have to undergo several investigations that are uncomfortable and difficult to perform. We think that the analysis of free IGF-1 may offer a better way of investigating children with poor growth. |
| Before we can find out exactly how valuable free IGF-1 may be in the investigation of children with growth disorders we need to know the concentration of free IGF-1 in the blood of healthy children. |
| The aim of the study is, therefore, to assess the concentration of free IGF-1 in the blood in healthy children and adolescents in relation to age, sex, and pubertal development. |
| This is the study plan: |
| • 1) We aim to investigate 1050 healthy children. |
| • 2) You will have a one-time blood sample taken between 8 and 9 am. You are not allowed to eat breakfast before the blood sample is taken. To reduce the discomfort of the blood sample a local anaesthetic will be applied to your skin. |
| • 3) You will be asked to collect a urine void in a little bottle. |
| • 4) You will have a doctor’s examination performed, your height and weight will be measured, and you will be asked to complete a questionnaire. |
| Two paediatric nurses and a paediatrician will take care of you during the study. |
| Participation in the study is, of course, voluntary. We understand and respect a refusal to participate. You/your child may withdraw at any time during the study, even after having given consent to the study. |