Cultural appropriateness of study procedure | 75/127 (59) | 19/30 (63) | 0.687 |
Need for local language consent form | 72/124 (58) | 27/32 (84) | 0.006* |
Relevance of research question to country where research is conducted and/or rationale for doing study outside the US | 63/116 (54) | 16/31 (52) | 0.842 |
Availability of intervention (if successful) to host country after study is over | 51/95 (54) | 11/24 (46) | 0.483 |
Need for letters of approval from developing country representatives | 53/114 (47) | 26/33 (79) | 0.001* |
Complexity of language on consent form | 54/120 (45) | 18/28 (64) | 0.070 |
Appropriateness of procedures for control group | 39/99 (39) | 12/24 (50) | 0.325 |
Use of placebos | 22/85 (26) | 5/23 (22) | 0.694 |
Participant voluntaries may be compromised because of benefits study provides | 27/112 (24) | 6/30 (20) | 0.644 |
Confidentiality protections for participants were not adequate | 22/121 (18) | 13/31 (42) | 0.004* |
Political considerations | 16/97 (16) | 4/24 (17) | 0.905 |
Intervention was considered too risky | 11/104 (11) | 4/26 (15) | 0.571 |
Others | 5/41 (12) | 1/12 (8) | 0.698 |