Table 2

 Concerns regarding participation in HIV/AIDS clinical drug trials

Primary topicConcerns
Antiretroviral continuationLifelong duration
Until physician tells patient to stop
Until a cure is available
Unless side effects or resistance mandate cessation
Duration clearly explained in consent process
Monetary compensationFor trial participation
To purchase antiretroviral therapy
To purchase food
Awareness of potential abuse
Patient/community education an additional compensation
Follow up and treatmentGeneral health care
Illness discovered during the trial
Iatrogenic adverse events
Moral obligationTo patient and community
For patients “helping” investigators
For benefits investigators acquire
For thorough informed consent
Paternalistic need to protect patient
Trial representation of all socioeconomic strata