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British transplant research endangered by the Human Tissue Act
  1. Antonia J Cronin1,
  2. Marlene Arlene L Rose2,
  3. John H Dark3,
  4. James F Douglas4
  1. 1NIHR Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, MRC Centre for Transplantation, King's College, London, UK
  2. 2Harefield Hospital, Imperial College, London, UK
  3. 3Institute of Cellular Medicine, Newcastle University, UK
  4. 4School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK
  1. Correspondence to Antonia J Cronin, NIHR Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust, and MRC Centre for Tran, MRC Centre for Transplantation, NIHR Biomedical Research Centre - Transplant Theme, King's College London, 5th Floor Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK; antonia.cronin{at}kcl.ac.uk

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Introduction

For over 50 years, research has made an invaluable contribution to the remarkable success of clinical transplantation. Landmark scientific discoveries include the description, development and practical use of HLA tissue typing,1–3 understanding of the role of antibodies in hyperacute rejection4 and the use and application of immunosuppressive treatment to prevent graft rejection.5 6

Transplantation has saved thousands of lives. Immunosuppressive protocols are highly sophisticated and transplant outcomes are better now than they have ever been. However, complications occur and challenges remain. Transplant outcomes could still be better. Progress depends on continuing scientific study of factors in both donor and …

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