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Assessment of the ethical review process for non-pharmacological multicentre studies in Germany on the basis of a randomised surgical trial
  1. C M Seiler1,
  2. P Kellmeyer2,
  3. P Kienle1,
  4. M W Büchler1,
  5. H-P Knaebel1,2,
  6. the INSECT Study Group
  1. 1Department of General, Visceral and Trauma Surgery, University of Heidelberg, Heidelberg, Germany
  2. 2Study Centre of the German Surgical Society (SDGC), Department of Surgery, University of Heidelberg Medical School, Heidelberg
  1. Correspondence to:
 C M Seiler
 Study Centre of the German Surgical Society (SDGC), Department of Surgery, University of Heidelberg Medical School, Im Neuenheimer Feld 110,D-69120 Heidelberg, Germany; christoph_seiler{at}med.uni-heidelberg.de

Abstract

Objective: To examine the current ethical review process (ERP) of ethics committees in a non-pharmacological trial from the perspective of a clinical investigator.

Design: Prospective collection of data at the Study Centre of the German Surgical Society on the duration, costs and administrative effort of the ERP of a randomised controlled multicentre surgical INSECT Trial (INterrupted or continuous Slowly absorbable sutures—Evaluation of abdominal Closure Techniques Trial, ISRCTN 24023541) between November 2003 and May 2005.

Setting: Germany.

Participants: 18 ethics committees, including the ethics committee handling the primary approval, responsible overall for 32 clinical sites throughout Germany. 8 ethics committees were located at university medical schools (MSU) and 10 at medical chambers. Duration was measured as days between submission and receipt of final approval, costs in euros and administrative effort by calculation of the product of the total number of different types of documents and the mean number of copies required (primary approval acting as the reference standard).

Results: The duration of the ERP ranged from 1 to 176 (median 31) days. The median duration was 26 days at MSUs compared with 34 days at medical chambers. The total cost was €2947. 1 of 8 ethics committees at universities (€250) and 8 of 10 at medical chambers charged a median fee of €162 (mean €269.70). The administrative effort for primary approval was 30. Four ethics committees required a higher administrative effort for secondary approval (37, 39, 42 and 104).

Conclusion: The ERP for non-pharmacological multicentre trials in Germany needs improvement. The administrative process has to be standardised: the application forms and the number and content of the documents required should be identical or at least similar. The fees charged vary considerably and are obviously too high for committees located at medical chambers. However, the duration of the ERP was, with some exceptions, excellent. A centralised ethics committee in Germany for multicentre trials such as the INSECT Trial can simplify the ERP for clinical investigators in and outside the country.

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Footnotes

  • Competing interests: None.

  • The local SDGC team: Study nurses: Dagmar Anders, Martina Bentner, Asli Istemihan, Sybille Jordan, Ruhan Koc, Stephanie Landgraf, Ingo Priebe and Anke Schwarz; Medical doctors: Dalibor Antolovic, Jeanine Bachmann, Markus Diener, Boris Fröhlich, Philipp Knebel, Moritz Koch, Margot Reidel, Stefan Sauerland and Moritz Wente. Recruitment was carried out by the participating surgical sites of the INSECT Study Group: Klinikum Augsburg, Stadtklinik Bad Toelz, St Josefs-Hospital Bochum, Klinikum links der Weser Bremen, Fuerst-Stirum-Klinik Bruchsal, St Josefs-Hospital Dortmund, Krankenhaus Gerresheim Duesseldorf, Chirurgische Universitätsklinik Erlangen, Krankenhaus Mittleres Erzgebirge, Evangelische Kliniken Gelsenkirchen, Waldklinikum Gera, Chirurgische Universitaetsklinik Heidelberg, Westkuestenklinikum Heide, Klinikum Herford, St Bonifatius-Krankenhaus Lingen, Klinikum Luedenscheid, Staedtisches Klinikum Magdeburg, Chirurgische Universitaetsklinik Marburg, Kreiskrankenhaus Mosbach, Chirurgische Universitaetsklinik Muenchen-Grosshadern, Chirurgische Universitaetsklinik Regensburg, Klinikum Suedstadt Rostock, Marienhospital Stuttgart, Robert-Bosch-Krankenhaus Stuttgart and Kreiskliniken Traunstein.

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