Consistency in decision making by research ethics committees: a controlled comparison
- 1Department of Health Sciences, University of Leicester, Leicester, UK
- 2Trent Research and Development Support Unit, Department of Health Sciences
- Correspondence to: M Dixon-Woods Department of Health Sciences, University of Leicester, 22-28 Princess Road West, Leicester LE1 6TP, UK;
- Received 30 August 2005
- Accepted 9 February 2006
- Revised 7 February 2006
There has been longstanding interest in the consistency of decisions made by research ethics committees (RECs) in the UK, but most of the evidence has come from single studies submitted to multiple committees. A systematic comparison was carried out of the decisions made on 18 purposively selected applications, each of which was reviewed independently by three different RECs in a single strategic health authority. Decisions on 11 applications were consistent, but disparities were found among RECs on decisions on seven applications. An analysis of the agreement between decisions of RECs yielded an overall measure of agreement of κ = 0.286 (95% confidence interval −0.06 to 0.73), indicating a level of agreement that, although probably better than chance, may be described as “slight”. The small sample size limits the robustness of these findings. Further research on reasons for inconsistencies in decision making between RECs, and on the importance of such inconsistencies for a range of arguments, is needed.
Competing interests: EA was employed as the Administrator to the Leicestershire, Northamptonshire and Rutland Research Ethics Committees during the period of the study. No other author has any conflict of interest.
Ethics approval: Support was sought and obtained from COREC in summer 2003. COREC confirmed that the project constituted service evaluation and development and therefore need not be reviewed by a Research Ethics Committee.